The World Health Organization reports there are an estimated 280 million people around the world suffering from depression. Depression affects over 16 million adults in the U.S. each year. Symptoms range from general irritation or sadness to abject hopelessness and suicidal ideation.
Many people between 15 to 29 years of age report thinking about death or self-harm. Suicide is the fourth most common cause of death in this age group. Around 700,000 people commit suicide each year, and depression is a factor in many of these deaths.
Ketamine is a short-acting anesthetic. Approved by the FDA in 1970, it was originally used to treat severely wounded soldiers during the Vietnam war. In recent decades and in addition to being used in hospitals, ketamine has been approved to treat a wide variety of conditions.
It is considered a “dissociative” anesthetic because it leaves sufferers feeling distant from their pain and surroundings. Ketamine can lead to a state of sedation (feeling calm and relaxed), immobility, and reprieve from pain. Many people undergoing ketamine treatment for depression report having feelings of euphoria and sometimes even psychedelic experiences.
This may sound intimidating if you have never experienced psychedelics but we can assure you, the process of a ketamine infusion or injection for depression is well worth the benefits and relief that result.
The team of experts at Daytryp will be able to answer any questions you may have prior to your ketamine infusion or injection so you will feel confident and prepared. We are here to support you every step of the way on your journey towards wellness.
Submit an inquiry and our team will help you find the best treatment options for you.
Research conducted in 2018 suggestions that ketamine treatment for depression may work by blocking glutamate via binding to N-methyl-D-aspartate (NMDA) receptors in the brain.
Glutamate is type of brain chemical called a neurotransmitter. It plays an important role in healthy brain function and regulating the nervous system. If glutamate receptors become and remain overstimulated, this may result in long term, chronic, or treatment resistant depression.
One popular theory about the efficacy of ketamine infusions for depression is their ability to repair neurons. A study published in 2018 showed that when people are exposed to long term stress, it wears away brain cells and can cause them to die off, resulting in depression. Ketamine actually encourages the formation of new neurons, relieving symptoms quickly.
While scientists are still studying the full effects, experts believe that ketamine’s interaction with brain receptors plays a pivotal role in its effects on effectively treating depression. Some are even calling ketamine for depression “the biggest breakthrough in depression research in 50 years.”
Selective serotonin reuptake inhibitors (SSRIs) are currently the leading treatment for depression in the US and include popular brands like Zoloft, Lexapro, and Zoloft. The simple explanation for how SSRIs work is that they increase serotonin levels in the brain.
Serotonin is a neurotransmitter that affects moods and emotions. In depressed patients, serotonin levels are lower than what is considered normal for healthy brain function. SSRIs inhibit the body from reabsorbing serotonin, resulting in higher levels and an alleviation of symptoms.
While SSRIs do appear to help people, they come with a variety of side effects that may be undesirable for the user.
Of all the psychiatric conditions, bipolar disorder carries the highest level of suicide. Ketamine for treating bipolar disorder shows promise because it creates new synaptic pathways in the brain; this is called synaptogenesis. This improves the body’s ability to regulate moods.
An article published by Samuel Wilkinson in the American Journal of Psychiatry reviewed ten distinct clinical studies that all conformed to a strict criterion. Fifty-five percent of the iv ketamine for depression study participants lost their suicidal ideation within a day; only 20 percent of the placebo group lost this ideation. These results lasted for a minimum of one week.
Ketamine can successfully treat depression, but it’s difficult to claim that depression can be cured. Daytryp Health patients should plan to take ketamine as a part of a comprehensive treatment plan for depression, as ketamine works best in combination with psychotherapy. This approach helps patients learn how to integrate any insight that may be gained during your ketamine session.
Psychotherapy, in conjunction with ketamine for depression, will help you adapt to circumstances by learning new behaviors and attitudes after the ketamine helps you break through internal barriers.
Ketamine treatments for depression are given in a controlled medical setting. Six to eight ketamine infusions or intramuscular shots will be given by a qualified member of the Daytryp staff, each lasting approximately 45 minutes. Sessions can be spread out over the course of several weeks.
Ketamine can be taken in pill form; these lozenges, called troches, are available by prescription and can be used in the comforts of your own home for maintenance after the original ketamine injections are administered. The effects are different for everyone but typically last around 45 minutes to an hour. According to the DEA, ketamine can remain in the body for 24 hours after ingestion.
The ketamine nasal spray, Spravato™, was approved by the FDA in 2019. It is meant to be used with an oral antidepressant for maximum efficacy. This treatment approach is indicated for treatment-resistant depression. Spravato™ nasal spray is self-administered under medical supervision at a certified clinic.
Ketamine results vary from one person to another, and the injection and/or infusion dosage will also vary based on the condition being treated and your bodyweight. Common experiences upon receiving ketamine include a dreamlike state, deep relaxation, and sometimes lucid memories of past events will surface. It may include visual or audial hallucinations, depending on the dosage given. The dosage will be determined by a Daytryp Health staff member after a complete evaluation.
When administered in a therapeutic setting, ketamine has little to no side effects, which is what makes it such a popular choice for those seeking relief from chronic conditions. The most common side effect associated with ketamine infusions is nausea, which can often be mitigated with clinical interventions. The anti-nausea medication Zofran can be given in the clinic if nausea arises, for example.
In addition to nausea, you can expect to feel a bit groggy after treatment. Most side effects do not last beyond a few hours. It is recommended to clear your schedule and to not have any plans after your ketamine treatment for depression.
Many of the patients we treat arrive mentally, emotionally, and physically drained from their conditions, yet remain hopeful. We are excited and so very grateful to be able to provide a treatment protocol that will result in not just the alleviation of symptoms for so many, but total wellness and transformation. Contact us today to get started!
Research trials have shown that patients treated with ketamine experience relief from anxiety, mood disorders, PTSD, chemical dependencies, chronic pain, major depression and treatment-resistant depression.
No drug has a rate of 100 percent success for treating depression but patients receiving treatment report immediate relief of symptoms. Ketamine for depression combined with psychotherapy is strongly recommended if you wish to free yourself from depression permanently.
Traditional medications often required many weeks before results could be observed; ketamine often works within 24 hours.
Ketamine blocks glutamatergic N-methyl-D-aspartate receptors; other medications like SSRIs affect the levels of serotonin, adrenaline or norepinephrine.
Ketamine promotes the nerve growth process called neurogenesis. This is what makes it effective at treating depression.
The efficacy of any ketamine depression treatment depends on a variety of factors. If current treatments fail to work, trying ketamine therapy can be immensely beneficial.
The Ketamine Advocacy Network estimates that the costs for ketamine treatments within the United States can range from $600-800 per infusion. This doesn’t include consultation costs, service fees, etc.
After the ketamine infusion, a sensation of lightness or floating will often be accompanied by pleasant sensations. Many people can process intense emotions without getting overwhelmed in this state. The senses are often more heightened. Sensitivity to light, sound and tactile sensations increase.
The FDA approved one form of ketamine in 2019 for the treatment of depression.
The first course of treatment lasts around four weeks. After this initial period, additional sessions might be required on an individual basis. For example, patients may contact the clinic to book another session if depression symptoms return after a few months.
The use of ketamine encourages new neural connections to form inside the brain, and this can reduce depression
Although there is almost no risk of ketamine making depression worse, in cases where high doses are taken, respiratory depression is a risk factor. This side effect can lead to respiratory failure in the most extreme cases.
Recreational use of Ketamine is illegal. A prescription is needed for the use of ketamine, and it is important to seek safe and secure care in a clinical setting.
Grounded in decades of extensive training with shamans, yogis, and spiritual teachers, Yvé
leverages her innate ability to channel the quantum field to provide profound insight and
transformation for her clientele. Her work is deeply influenced by her daily meditation practice, esoteric research, quantum mechanics, and J.R.R. Tolkien… only partially a joke!
Yvé’s advocacy for Divine Neutrality inspired her exploration into the transformative potential of Ketamine therapy. She delights in her role as a Tryp Guide, where she creates and holds sacred space, promoting transformation through this unique modality. Graced with an amazing partner and soul community, Yvé is humbled and honored to share her life’s purpose with you.
Will has spent his life seeking truth and exploring the limits of what is possible. This has led him to many extreme experiences—Marine Corps combat veteran, US Army Airborne and Ranger schools, wilderness adventure racing, high altitude mountaineering, ultra-endurance events, holistic healing modalities, psychedelics, and coaching.
Will is a Co-Active Certified Professional Coach and a High Flow Performance Coach. He specializes in integrative psychedelic coaching and facilitating psychedelic experiences. He is relentless in his passion to explore life’s magnificence. It’s an ongoing journey and one he would be honored to share with you as a Tryp Guide.
While everyone has a different path to happiness, the majority of people encounter comparable experiences along the way. Examples include honesty, kindness, compassion, generosity, concern for oneself, others, and nature; respect for life; a desire to make a good difference; and many more.
Steve’s involvement, acceptance, and advocacy of the use of entheogenic substances as sacraments for direct spiritual experiences is what has inspired him to work hard to create peace and harmony in both his own life and the lives of those around him.
Steve has made a commitment to rejuvenating his own spiritual life using humanist resources and a humanist perspective. With an emphasis on the mysticism of the unitive experience and the practical use of entheogenic rituals for learning about and developing human consciousness to create a direct connection to the Divine within, Steve has been studying and using a variety of transformational tools. Each has acted as a catalyst in his own consciousness, resulting in profoundly life-altering experiences that have gradually revealed Steve’s true self and pointed him in the direction of his true purpose in life.
Steve’s desire to be of service to others by coaching, mentoring, and guiding them through a shamanic methodology and the practical use of entheogenic rituals is the driving force behind his life’s work, passions, and interests.
Steve loves sharing the knowledge he has gained using many entheogenic sacraments and transformational tools that can help spark a shift in consciousness and result in a profound realization of one’s true nature. Steve also firmly endorses both the idea of cognitive liberty (the right to direct one’s own consciousness) and the safe and appropriate use of entheogenic sacraments for a direct spiritual experience.
Steve has put a lot of effort into learning about and developing the best techniques as a practitioner and guide to provide the right guidance, proper preparation, safe navigation, and holistic integration into the sacred work he performs, and he remains dedicated to his work through practice, mentorship, and study.
There is a prayer in Sanskrit, one of the oldest recorded languages dating back 7000–8000 years, that says, “Lokah Samastah Sukhino Bhavantu.” This means: “May all beings everywhere be happy and free. May the thoughts, words, and actions of my own life contribute in some way to that happiness and that freedom for all.” This is a truth Steve lives by every day.
Megan is passionate about holding a sacred space for others to explore healing connections between the mind, body, breath, and spirit. As a plant energy practitioner, essential oils specialist, and yoga teacher, she wholeheartedly believes in an individualized approach to health and the power of curating personalized integrative self-healing practices of your own. Megan creates space for others to explore the therapeutic benefits of psychedelic medicines, both from a physiological and metaphysical standpoint, while inspiring others remembrance of their divine beauty, purpose, and gifts. Through the art of intention, peaceful presence, and loving awareness she hopes to welcome you more deeply into accessing your innate power to heal from within.
From a young age, Joel sought happiness in competitive sports, business, and relationships. Each accomplishment came with a fleeting sense of fulfillment causing another repeat of the same cycle. That same mysterious desire for acceptance led Joel to seek information in new and unfamiliar territories. Joel has found comfort in his study of past and current visionaries, such as Carl Jung, Dr. Richard Schwartz, Deepak Chopra, and Gabor Matè. Learning that love of oneself is the true path to peace. Joel honors medicines and substance along with meditation and self-care for the aid of self-discovery. He has found that nothing is more enjoyable than supporting others in their constant journey of growth. Healing himself and others has become his greatest gift and passion.
Nick’s upbringing instilled in him the significance of giving, helping, and inspiring others. He understands that these invaluable gifts have the power to shift paradigms within one’s life. For him, being involved in someone’s transformative journey is a privilege. Deep within each of us lies the ability to discover peace and lasting happiness. Sometimes we just need someone to guide us along the way. Nick carries this responsibility close to his heart, knowing firsthand the vulnerability we experience when seeking help. He hopes to be a bright light throughout this magnificent adventure you are about to embark upon.
Ann is a registered nurse with a passion for helping others find balance in wellness and health. After graduating with her BSN from Cleveland State University in 2013, she worked briefly as a progressive care cardiac nurse. During that time, she was trained in Usui Reiki and completed her master/teacher level training in 2014. She then devoted herself as a hospice nurse, supporting and coaching many individuals and their loved ones through the dying process. After several years, Ann transitioned her skills and desires to focus on helping individuals achieve optimal wellness with holistic therapies. She opened a small mobile IV infusion business in 2019, offering in-home infusion therapy focusing on prevention and health maintenance. She also became certified in medical aesthetics.
Her constant ambition as a nurse is in service and helping others activate their own healing for optimal wellness while living from their highest self. Her goal is to provide a calm and peaceful environment where individuals can relax into healing.
She grew up in Latrobe, Pennsylvania and has lived in sunny Arizona since 2015. She finds relaxation in the outdoors, hiking, kayaking, star-gazing and flying airplanes.
Alisia graduated from Arizona State University with a Bachelor of Science in Nursing in 2011. She has worked in both outpatient and inpatient settings during her 12 years as a RN. Her fascination with the human brain led her to become a specialist in Deep Brain Stimulation therapy. Alisia is also an artist and has been selling her work professionally for the last 10 years. Through several difficult life events, she experienced firsthand the healing power of creative expression. Her passions reside in health, psychology, art, and human connection. She is ecstatic to be part of the Daytryp team, and grateful for the opportunity to assist with the intentional use of psychedelic medicines for healing.
Nellietha (Nellie) has been in healthcare for 18 years. She graduated with a Bachelors in Science from Chamberlain College of Nursing in 2018. She grew up in a family that prioritized alternative medicine and witnessed firsthand the profound impact natural remedies have on physical and mental health. As someone who has personally experienced the transformative effects of psychedelics, she is passionate about helping others find relief and healing through these alternative therapies. In her free time, she enjoys her animals, gardening, and being out in nature.
David Romanelli fuses ancient wellness practices with modern passions that give people accessible tools to overcome stress, focus their mind, and improve their relationships at work and home. David’s third book, Life Lessons from the Oldest and Wisest, is a reminder that countless professionals, parents, and partners have walked the earth before us. The book was inspired by his series of national events called DRINKS WITH YOUR ELDERS, that created a space for isolated elders to reengage with their community and share their life experiences with younger generations. His previous book, Happy is the New Healthy, was inspired by David’s friendship with a 111 year-old New Yorker. The book reached #1 on multiple Amazon and Apple Bestseller Lists.
Dave partnered up with Daytryp Health to create TRIPT, which is a psychedelic integration APP which is offered to all Daytryp clients.
Most recently, David was a featured voice on a new app from Calm, which brings peace of mind and healing techniques to the 1 of every 3 Americans touched by cancer. His daughter Cooper (aka SuperCooper) put leukemia in the rear view mirror and is David’s inspiration everyday to live with strength, passion, and joie de vivre. Throughout Cooper’s treatment, David found the power of psychedelic therapy as a profound way to heal the trauma and constant worry and reset to a positive path forward as parent, partner, and professional.. His 365 day platform, MEDITATE ON, compels his listeners to gain perspective on their journey and take time each day for reflection, quiet, and meditation. David has been featured in The New York Times, Food & Wine, Wall Street Journal, and Newsweek. You can learn more at www.DavidRomanelli.com
Furthermore, Dave is in charge of Daytryp Retreats, which brings people from all over the world to Phoenix, AZ for 3-4 day retreats to experience life-changing psychedelic journeys.
Medical Advisor / Tryp Guide
Dr. Joe Tafur has dedicated his career to exploring complementary and alternative approaches to health management, particularly Amazonian plant medicines. He completed a Post-Doctoral Research Fellowship at UCSD Department of Psychiatry, and worked as a Family Physician in the US before exploring indigenous medicine in South America (SA). He helped found Nihue Rao Centro Espiritual, a traditional healing center in the Peruvian Upper Amazon, and underwent apprenticeship in Traditional Amazonian Plant Medicine and Shipibo curanderismo. In 2017, Dr. Joe founded Modern Spirit, a 501c3 nonprofit focused on demonstrating the value of spiritual healing in modern healthcare. In 2019, he and his colleagues opened the Ocotillo Center for Integrative Medicine. Dr. Tafur is also a leader in his spiritual community and leads plant medicine journeys across the continent. Joe is also a best selling author with his book, The Fellowship of the River.
Lead Tryp Guide & Operations Manager
MSN, APRN, ANP-C, Medical Director
Chief Medical Officer
Founder & CEO
MS, LASAC, Consultant/Integration Therapist
Rudy Montijo lends his expertise in operations and business development consulting for Daytryp. He received his undergraduate from the University of Arizona, a master’s degree in Addiction Counseling from Grand Canyon University, and Ketamine Assisted Psychotherapy training from Polaris Insight. Rudy worked under Daytryp’s founder and CEO, Chris Cohn, while operating and expanding Scottsdale Recovery Center from 2013-2014. He currently has an award-winning career in medical sales. He is a former D1 athlete, having played football at the University of Arizona. Rudy is a clinical therapist who is trained in ketamine-assisted psychotherapy, actively races on the Ironman triathlon circuit, and is a certified yoga instructor. After helping others, Rudy’s greatest love is his two children, River and Savanna.